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The recommended initial dose, titration, dose range and maximum SEROQUEL dose for each approved indication is displayed in Table 1. Based on response and tolerability, may be administered three times daily. When the CYP3A4 inhibitor is discontinued, the dose of SEROQUEL should be increased by 6 fold SEROQUEL dose should be increased up to 5 fold of the orinal dose when used in combination with a chronic treatment (e.g., greater than 7-14 days) of a potent CYP3A4 inducer (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St. The dose should be titrated based on the clinical response and tolerability of the individual patient.

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Quetiapine, marketed as Seroquel, is an atypical antipsychotic approved for the treatment of schizophrenia, bipolar disorder, and along with an antidepressant to treat major depressive disorder.

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Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.


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