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GAD: Initially 75mg once daily; may start at 37.5mg once daily for 4–7 days before increasing to 75mg/day; may increase by increments of up to 75mg/day at intervals of at least 4 days. PD: Initially 37.5mg once daily for 7 days, then may increase to 75mg/day; then may increase in increments of up to 75mg/day at intervals of at least 7 days. Mild-to-moderate hepatic impairment: reduce by 50%. Renal impairment: reduce by 25–50%; reduce dose by 50% in hemodialysis (hold dose until end of treatment).
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Pre-existing hypertension, cardio- or cerebrovascular disease. Monitor BP before and during treatment; consider dose reduction or discontinuation if elevated BP persists.
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In the US, Venlafaxine (venlafaxine systemic) is a member of the drug class serotonin-norepinephrine reuptake inhibitors and is used to treat Anxiety, Anxiety and Stress, Autism, Bipolar Disorder, Bulimia, Cataplexy, Depression, Dissociative Identity Disorder, Fibromyalgia, Generalized Anxiety Disorder, Hot Flashes, Irritable Bowel Syndrome, Major Depressive Disorder, Mraine, Obsessive Compulsive Disorder, Panic Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Social Anxiety Disorder, Somatoform Pain Disorder and Vulvodynia.
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