Colchicine and iv and poisoning

Colchicine oral Uses, Side Effects, Interactions.

I’ve always thought that colchicine was an awful drug, and that the recommendations for its use in the emergency department didn’t make sense. Colchicine is a feared poison — it impairs the function of cellular microtubules, interfering with essential processes such as mitosis, secretion, protein synthesis, and myocardial function.

Colchicine Toxicity Deadly Face of a Familiar Friend.

Vomiting and diarrhoea commonly occur when colchicine is repeatedly dosed at 1-hour or 2-hour intervals for acute gout.1,3 These are the first sns of colchicine toxicity, and may precede rare adverse effects including muscle damage, neuropathy, multiple organ failure and bone marrow suppression.4 Patients with renal or hepatic impairment may be particularly susceptible to severe colchicine toxicity (Box 2).2,5-7 Increasing awareness of toxicity led prescribing guidelines to recommend lower colchicine doses and extended dosing intervals.8-10 Case reports and expert opinion suggested that the treatment benefit could be maintained at lower colchicine doses, but no data from controlled trials were available until recently.1,11 Recent trial evidence demonstrates that low-dose colchicine (2 tablets followed by 1 tablet 1 hour later) is effective when prescribed within 12 hours of onset of an acute gout flare, with a low incidence of gastrointestinal adverse effects (Table 1).1 A hher dose (2 tablets followed by 1 tablet every hour for 6 hours) offered no additional clinical benefit, but increased the risk of gastrointestinal toxicity.

Questions <b><b>and</b></b> Answers About FDA's

Colchicine PIM 141 - ipcs inchem

This medication is used to prevent or treat gout attacks (flares).

Colchicine Poisoning

Colchicine alkaloids are found in the plants Colchicum autumnale (autumn crocus, also known as meadow saffron) and Gloriosa superba (glory lily). Olson, MD; CPCS Managing Directors: Judith Alsop, Pharm D, Thomas E.


Colchicine and iv and poisoning:

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