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Heart attack and heart failure patients have a hher risk of a second heart attack or death if they take painers including the generic drug ibuprofen and Pfizer Inc's Celebrex, a Danish study found and Vioxx, two prescription pain medications primarily intended to help arthritis sufferers, have recently come under tough scrutiny and were almost pulled from the market because their use substantially increases the risks of serious complications--such as heart attacks, strokes, and cardiovascular disorders.

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CELEBREX may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. NSAIDs, including CELEBREX, cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

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